Conflict of interests: The authors declare no conflict of interest.
Meta-Analysis and Systematic Review
Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis
Version of Record online: 20 JUN 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 7, pages 1114–1121, July 2013
How to Cite
Yang, M., Rao, H.-Y., Feng, B., Zhang, W. and Wei, L. (2013), Impact of interleukin 28B polymorphisms on spontaneous clearance of hepatitis C virus infection: A meta-analysis. Journal of Gastroenterology and Hepatology, 28: 1114–1121. doi: 10.1111/jgh.12233
- Issue online: 20 JUN 2013
- Version of Record online: 20 JUN 2013
- Accepted manuscript online: 23 APR 2013 06:21AM EST
- Manuscript Accepted: 7 APR 2013
- National Science and Technology Major Project for Infectious Diseases Control. Grant Numbers: 2008ZX10002-012, 2008ZX10002-013, 2012ZX10002003
- hepatitis C virus;
- interleukin 28B;
- single nucleotide polymorphisms;
- spontaneous clearance
Background and Aim
Recent studies suggested that interleukin 28B (IL28B) polymorphisms may affect spontaneous clearance (SC) of hepatitis C virus (HCV) infection. Our purpose was to update the meta-analysis to reevaluate the impact of IL28B rs12979860 and rs8099917 polymorphisms on SC in patients infected with HCV.
We searched PubMed, Web of Science, and Embase up to February 2013. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by fixed- or random-effects models. Heterogeneity, sensitivity analysis, and publication bias were also assessed.
Seventeen eligible papers were involved in this study. The SC rate was higher in patients with the rs12979860 CC (vs CT/TT OR = 2.98, 95% CI 2.53–3.50) and rs8099917 TT (vs GT/GG OR = 2.80, 95% CI 2.23–3.51) in the IL28B polymorphisms. Ethnicity stratification revealed that rs12979860 CC was associated with SC for Caucasians (vs CT/TT OR = 3.05, 95% CI 2.67–3.49), Asians (vs CT/TT OR = 1.88, 95% CI 1.33–2.66), and Africans (vs CT/TT OR = 3.15, 95% CI 2.39–4.15); rs8099917 TT was associated with SC for Caucasians (vs GT/GG OR = 2.48, 95% CI 1.96–3.15).
IL28B rs12979860 and rs8099917 single nucleotide polymorphisms are significantly associated with SC of HCV infection. The predictive value of rs12979860 CC was stronger in Caucasians and Africans than in Asians.