Financial support: This study was partially supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan for Research on Intractable Diseases and Portal Hemodynamic Abnormalities.
Obliteration of gastric varices improves the arrival time of ultrasound contrast agents in hepatic artery and vein
Article first published online: 22 AUG 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 9, pages 1526–1531, September 2013
How to Cite
Furuichi, Y., Moriyasu, F., Sugimoto, K., Taira, J., Sano, T., Miyata, Y., Sofuni, A., Itoi, T., Nakamura, I. and Imai, Y. (2013), Obliteration of gastric varices improves the arrival time of ultrasound contrast agents in hepatic artery and vein. Journal of Gastroenterology and Hepatology, 28: 1526–1531. doi: 10.1111/jgh.12234
Conflict of interest statement: None of the authors have any conflicts of interest associated with this study.
- Issue published online: 22 AUG 2013
- Article first published online: 22 AUG 2013
- Accepted manuscript online: 23 APR 2013 06:22AM EST
- Manuscript Accepted: 7 APR 2013
- Ministry of Health, Labour and Welfare of Japan
- balloon-occluded retrograde transvenous obliteration (B-RTO);
- contrast-enhanced ultrasonography (CEUS);
- hyperdynamic circulatory state;
- Kupffer cells;
- transit time
Background and Aim
Liver cirrhosis (LC) is accompanied by hepatic arterializations, intrahepatic shunts, and hyperdynamic circulations. These changes shorten the arrival time (AT) of ultrasound contrast agents to the hepatic vein (HV). Whether treatment of gastric fundal varices (GVs) by balloon-occluded transvenous obliteration (B-RTO) improves the AT in LC patients was prospectively investigated.
A total of 32 LC patients with GVs and 10 normal controls (NCs) were enrolled. This study was approved by the clinical research ethics committee. Images of hepatic artery (HA), portal vein (PV), and HV were monitored after an injection of a contrast agent using quantification software. The AT before and after B-RTO in LC patients and that in NCs were compared.
All GVs were treated effectively, and indocyanine green retention rate was improved (P < 0.0001). The mean values of the HA, PV, and HV ATs in the NCs were 21.9 ± 3.3, 28.2 ± 2.0, and 40.5 ± 2.1 s, respectively. Those in LC patients were 17.4 ± 4.4, 21.9 ± 5.6, and 26.3 ± 6.7, respectively, which were shorter than those in NCs (P < 0.01, P < 0.002, P < 0.0001, respectively). However, these ATs were significantly prolonged 1 week after B-RTO, with mean values of 18.7 ± 4.8, 23.8 ± 6.0, and 30.0 ± 7.2 s (P = 0.043, P < 0.01, P < 0.001).
Obliteration of GVs shifted the AT in LC patients to the normalization, raising the possibility of improvement of arterialization and intrahepatic shunt.