Nutritional components regulate the gut immune system and its association with intestinal immune disease development

Authors

  • Aayam Lamichhane,

    1. Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan
    3. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
    4. Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka, Japan
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  • Hiroshi Kiyono,

    1. Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan
    3. International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    4. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
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  • Jun Kunisawa

    Corresponding author
    1. Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan
    3. International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    4. Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka, Japan
    5. Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    • Correspondence

      Dr Jun Kunisawa, Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan. Email: kunisawa@nibio.go.jp

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Abstract

The gut is equipped with a unique immune system for maintaining immunological homeostasis, and its functional immune disruption can result in the development of immune diseases such as food allergy and intestinal inflammation. Accumulating evidence has demonstrated that nutritional components play an important role in the regulation of gut immune responses and also in the development of intestinal immune diseases. In this review, we focus on the immunological functions of lipids, vitamins, and nucleotides in the regulation of the intestinal immune system and as potential targets for the control of intestinal immune diseases.

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