Conflict of interest: None.
Gilbert's syndrome and the risk of death: A population-based cohort study
Article first published online: 23 SEP 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 10, pages 1643–1647, October 2013
How to Cite
Horsfall, L. J., Nazareth, I., Pereira, S. P. and Petersen, I. (2013), Gilbert's syndrome and the risk of death: A population-based cohort study. Journal of Gastroenterology and Hepatology, 28: 1643–1647. doi: 10.1111/jgh.12279
Financial support: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
- Issue published online: 23 SEP 2013
- Article first published online: 23 SEP 2013
- Accepted manuscript online: 22 MAY 2013 06:40AM EST
- Manuscript Accepted: 4 MAY 2013
- bilirubin uridine-diphosphoglucuronosyl transferase 1A1;
- Gilbert disease;
Background and Aims
Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates in those with and without Gilbert's syndrome.
Mortality rates in patients with a diagnosis of Gilbert's syndrome and raised bilirubin level (n = 4266) were compared with those of patients with similar characteristics but with normal bilirubin levels (n = 21 968). Multivariate Poisson regression was also used to estimate adjusted mortality rate ratios.
During the 350 000 PYs of follow up across the Gilbert's and comparison cohorts, there were 1174 deaths. Mortality rates were 24/10 000 PYs in the Gilbert's cohort versus 50/10 000 PYs in the comparison cohort. Mortality rates were around half in patients with Gilbert's syndrome after accounting for sociodemographics and general health indicators (adjusted mortality rate ratio: 0.5 [95% confidence interval; 0.4–0.7; P < 0.001]).
Mortality rates observed for people with Gilbert's syndrome in the general population are almost half those of people without evidence of Gilbert's syndrome.