These authors contributed equally to this work.
Normative data of high-resolution impedance manometry in the Chinese population
Article first published online: 23 SEP 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 10, pages 1611–1615, October 2013
How to Cite
Shi, Y., Xiao, Y., Peng, S., Lin, J., Xiong, L. and Chen, M. (2013), Normative data of high-resolution impedance manometry in the Chinese population. Journal of Gastroenterology and Hepatology, 28: 1611–1615. doi: 10.1111/jgh.12285
Conflicts of interest: The authors do not have any conflicts of interest.
Funding: This work was supported by the following grants: Science and Technology Planning Project of Guangzhou, China (Minhu Chen 2010GN-E00221); the Research Fund for the Doctoral Program of Higher Education of China 20110171120080 (Yinglian Xiao); Science and Technology Planning Project of Guangdong Province, China 2011B031800121(Sui Peng).
- Issue published online: 23 SEP 2013
- Article first published online: 23 SEP 2013
- Accepted manuscript online: 4 JUN 2013 05:10AM EST
- Manuscript Accepted: 12 MAY 2013
- Science and Technology Planning Project of Guangzhou, China. Grant Number: 2010GN-E00221
- Research Fund for the Doctoral Program of Higher Education of China. Grant Number: 20110171120080
- Science and Technology Planning Project of Guangdong Province, China. Grant Number: 2011B031800121
- Chicago classification;
- esophageal manometry;
- high-resolution manometry
Background and Aim
Current normative data of high-resolution manometry have been obtained from Western populations, and esophageal motility disorders have been categorized using Chicago classification. However, the utility of high-resolution impedance manometry (HRiM) in the Chinese population has not been evaluated. The study aimed to investigate the normal reference of esophageal motility in healthy volunteers (as defined by Chicago classification) using HRiM.
Healthy, fasted volunteers underwent HRiM in a supine position with 10 liquid swallows and 10 viscous swallows. Integrated relaxation pressure (IRP), distal contractile integral (DCI), contractile front velocity (CFV), and distal latency were calculated. The interquartile ranges and the 95th percentile range for each metric were obtained.
Forty-two healthy volunteers were enrolled with 411 total liquid swallows and 398 viscous swallows available for analysis. A 20.5 mmHg of IRP and a 3195 mmHg·s·cm of DCI as the 95th percentile for liquid swallows were established. Using the reference range defined by Chicago classification, 6.3% (26/411) weak peristalsis and 0.7% (3/411) failed peristalsis for liquid swallows were observed; 12 (28.6%, 12/42) and 2 (4.7%, 2/42) individuals were diagnosed as esophagogastric junction outflow obstruction and weak peristalsis for liquid swallows. Compared with liquid swallows, viscous swallows had a decreased IRP (P = 0.000) and CFV (P = 0.000), and an unchanged DCI (P = 0.211).
HRiM normative data of both liquid and viscous swallows from healthy Chinese volunteers were established. The IRP and CFV were significantly decreased in the viscous swallows compared with those of the liquid swallows.