Conflict of interest: There is no conflict of interest to report.
Clinical outcome of sorafenib treatment in patients with advanced hepatocellular carcinoma refractory to hepatic arterial infusion chemotherapy
Article first published online: 22 NOV 2013
© 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd
Journal of Gastroenterology and Hepatology
Volume 28, Issue 12, pages 1834–1841, December 2013
How to Cite
Miyaki, D., Aikata, H., Kan, H., Fujino, H., Urabe, A., Masaki, K., Fukuhara, T., Kobayashi, T., Naeshiro, N., Nakahara, T., Kawaoka, T., Hiramatsu, A., Takahashi, S., Ishikawa, M., Kakizawa, H., Awai, K. and Chayama, K. (2013), Clinical outcome of sorafenib treatment in patients with advanced hepatocellular carcinoma refractory to hepatic arterial infusion chemotherapy. Journal of Gastroenterology and Hepatology, 28: 1834–1841. doi: 10.1111/jgh.12311
- Issue published online: 22 NOV 2013
- Article first published online: 22 NOV 2013
- Accepted manuscript online: 28 JUN 2013 05:52AM EST
- Manuscript Accepted: 17 JUN 2013
Background and Aim
It has been reported about poor prognosis in patients with advanced hepatocellular carcinoma (HCC) refractory to hepatic arterial infusion chemotherapy (HAIC). We assessed the survival benefits of sorafenib therapy for advanced HCC in HAIC refractory patients.
The study subjects were 191 patients with advanced HCC who had been treated with HAIC. Sorafenib was used in 27 patients who finally failed to respond to HAIC (HAIC/sorafenib group). Clinical outcome was compared between HAIC/sorafenib and HAIC alone groups.
There were no significant differences in clinical characteristics and response rate of HAIC between the two groups (response rate: 25.9%, HAIC/sorafenib group; 30.4%, HAIC alone group). The median survival time (MST) for all patients was 11.0 months. The survival rate was significantly higher in the HAIC/sorafenib group than HAIC alone group (MST 22.2 vs 8.7 months, P = 0.017). From administration sorafenib, the disease control rate was 51.8% with MST of 10.4 months. Among HAIC non-responders, the survival rate was significantly higher in the HAIC/sorafenib group than HAIC alone group. Multivariate analysis identified additional therapy with sorafenib as significant and independent determinant of overall survival in all patients and HAIC non-responders.
Additional therapy with sorafenib could probably improve the prognosis of HAIC refractory patients.