Aspirin Use After Diagnosis Improves Survival in Older Adults with Colon Cancer: A Retrospective Cohort Study
Article first published online: 23 NOV 2012
© 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 60, Issue 12, pages 2232–2236, December 2012
How to Cite
Reimers, M. S., Bastiaannet, E., van Herk-Sukel, M. P. P., Lemmens, V. E. P., van den Broek, C. B. M., van de Velde, C. J. H., de Craen, A. J. M. and Liefers, G. J. (2012), Aspirin Use After Diagnosis Improves Survival in Older Adults with Colon Cancer: A Retrospective Cohort Study. Journal of the American Geriatrics Society, 60: 2232–2236. doi: 10.1111/jgs.12033
- Issue published online: 11 DEC 2012
- Article first published online: 23 NOV 2012
- colon cancer;
To assess survival in relation to aspirin use after diagnosis in older adults with colon cancer.
Subgroup analysis of a previously published cohort and retrospective study.
Individuals registered in the Eindhoven Cancer Registry (ECR) between 1998 and 2007, linked to prescriptions of low-dose aspirin (80 mg) registered in a community pharmacy database.
Five hundred thirty-six individuals aged 70 and older diagnosed with colon cancer with or without aspirin use after diagnosis.
Survival was analyzed with user status as a time-dependent covariate. Multivariate Poisson regression survival models were used to study the effect of aspirin on overall survival.
One hundred seven participants (20.0%) started aspirin after being diagnosed with colon cancer; 429 (80.0%) were not prescribed aspirin. Three hundred thirty-nine participants (63.2%) had died by the end of follow-up. Aspirin use after diagnosis was associated with longer overall survival (rate ratio (RR) = 0.51, 95% confidence interval (CI) = 0.38–0.70, P < .001). Multivariate proportional hazards regression analysis revealed that aspirin use was associated with longer overall survival (adjusted RR = 0.59, 95% CI = 0.44–0.81, P = .001).
Aspirin use after the diagnosis of colon cancer in older adults was associated with longer survival. Low-dose aspirin could be used as an effective adjuvant therapy in older adults with colon cancer.