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Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study

Authors

  • Claire Roubaud Baudron MD, MSc,

    Corresponding author
    1. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
    2. Pôle de Gérontologie Clinique, CHU Hôpitaux de Bordeaux, Bordeaux, France
    • INSERM, U853, Bordeaux, France
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  • Luc Letenneur PhD,

    1. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
    2. Pôle de Gérontologie Clinique, CHU Hôpitaux de Bordeaux, Bordeaux, France
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  • Anthony Langlais MSc,

    1. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
    2. INSERM, U897, Bordeaux, France
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  • Alice Buissonnière,

    1. INSERM, U853, Bordeaux, France
    2. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
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  • Francis Mégraud MD, PhD,

    1. INSERM, U853, Bordeaux, France
    2. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
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  • Jean-François Dartigues MD, PhD,

    1. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
    2. INSERM, U897, Bordeaux, France
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  • Nathalie Salles MD, PhD,

    1. INSERM, U853, Bordeaux, France
    2. Laboratoire de Bactériologie, University of Bordeaux, Bordeaux, France
    3. Pôle de Gérontologie Clinique, CHU Hôpitaux de Bordeaux, Bordeaux, France
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  • for the Personnes Agées QUID Study


  • [Editorial Comments by Dr. Joe Verghese, pp 000–000]

Address correspondence to Dr. Claire Roubaud Baudron, INSERM U853, Université Bordeaux Segalen, Carreire zone nord Bat 2B RDC, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. E-mail: claire.roubaud@chu-bordeaux.fr

Abstract

Objectives

To determine whether Helicobacter pylori infection was associated with dementia and risk of developing dementia in a longitudinal population-based cohort of elderly adults living in the community.

Design

Prospective community-based cohort study.

Setting

The population-based Personnes Agées QUID (PAQUID) Study.

Participants

Six hundred three noninstitutionalized individuals aged 65 and older living in the southwest of France followed from 1989 to 2008.

Measurements

A descriptive and comparative analysis including dementia prevalence, according to H. pylori status (serology), was made at baseline. Cox proportional hazard models were used to study the risk of developing dementia according to H. pylori status assessed on sera samples from elderly adults initially free of dementia and followed for 20 years. A neurologist diagnosed dementia according to Diagnostic and Statistical Manual of Mental Disorders Third Edition criteria.

Results

At baseline, 391 (64.8%) subjects (348 women, mean age 73.9 ± 6.5) were seropositive for H. pylori. Dementia prevalence was higher in the infected group (5.4% vs 1.4%, = .02). After 20 years of follow-up, 148 incident cases of dementia were diagnosed. After controlling for age, sex, educational level, apolipoprotein E4 status, cardiovascular risk factors, and Mini-Mental State Examination score, H. pylori infection was determined to be a risk factor for developing dementia (hazard ratio = 1.46, = .04).

Conclusion

This longitudinal population-based study provides additional epidemiological support to the hypothesis of an association between dementia and H. pylori infection, which may enhance neurodegeneration.

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