Adverse Oral Health and Cognitive Decline: The Health, Aging and Body Composition Study
Version of Record online: 13 FEB 2013
© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 61, Issue 2, pages 177–184, February 2013
How to Cite
Stewart, R., Weyant, R. J., Garcia, M. E., Harris, T., Launer, L. J., Satterfield, S., Simonsick, E. M., Yaffe, K. and Newman, A. B. (2013), Adverse Oral Health and Cognitive Decline: The Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 61: 177–184. doi: 10.1111/jgs.12094
- Issue online: 13 FEB 2013
- Version of Record online: 13 FEB 2013
- Wellcome Trust
- University of Padua
- University of Verona
- Imperial College London
- Imperial College London and children's stock holding in Web MD
- U.S. Public Health Service. Grant Numbers: N01-AG-6–2103, 1R01AG028050, N01-AG-6–2106
- NIH. Grant Numbers: N01-AG-6–2103, 1R01AG028050, N01-AG-6–2106
- National Institute for Health Research (NIHR)
- NIHR Specialist Biomedical Research Centre for Mental Health
- Maudsley National Health Service Foundation Trust
- Institute of Psychiatry, King's College London
- National Institute for Drug Abuse
- National Institute for Dental and Craniofacial Research
- the Health Resources and Services Administration
- U.S. federal government and academic centers. Grant Numbers: N01-AG-6–2103, 1R01AG028050, N01-AG-6–2106
- cognitive decline;
- cognitive impairment;
- periodontal disease;
To investigate the relationship between periodontal disease and cognitive decline.
Analysis of a prospective cohort study.
The Health, Aging and Body Composition (Health ABC) Study.
One thousand fifty-three participants who were administered the Modified Mini-Mental State Examination (3MS) at Year 1 (baseline) and Year 3 and had participated in a comprehensive periodontal examination at Year 2.
The prospective association between a range of oral health parameters and cognitive function was examined. Decline in 3MS score from Year 3 to 5 was investigated in 947 (89.9%) participants. Covariates included age, sex, education, race, cardiovascular disease and risk, and depressive symptoms.
Most indicators of adverse oral health at Year 2 were associated with cognitive impairment based on averaged 3MS scores less than 80 for Years 1 and 3, but education and race substantially confounded these associations. Higher gingival index, a measure of gingival inflammation, at Year 2 remained independently associated with this definition of cognitive impairment and, in fully adjusted analyses, was also an independent predictor of a more-than-5-point cognitive decline from Year 3 to 5.
Periodontitis may be a risk factor for cognitive decline. Gingivitis is reversible, and periodontitis to some degree is preventable and controllable when manifest. Therefore, further research is needed to clarify potential underlying mechanisms and oral health interventions that might ameliorate cognitive decline.