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Data S1. Assessment of interaction in a Cox PH model on the additive scale.

Data S2. Study sample selectivity.

Figure S1. All-cause mortality versus ApoE4 dosage.

Figure S2. All-cause mortality versus dementia status and MCI status (Time-dependent).

Figure S3. All-cause mortality versus AD status and non-AD status (Time-dependent).

Figure S4. All-cause mortality versus sex.

Table S1. All-cause, cardiovascular and non-cardiovascular mortality by ApoE4 carrier status, dosage and by sex, stratified by time-dependent cognitive status: Cox PH and competing risk models; Baltimore Longitudinal Study of Aging.

Table S2. All-cause, cardiovascular and non-cardiovascular mortality by ApoE4 carrier status and dosage, and by time-dependent cognitive status, stratified by sex: Cox proportional hazards and competing risk models; Baltimore Longitudinal Study of Aging.

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Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.