Independent and Combined Effects of Physical Activity and Weight Loss on Inflammatory Biomarkers in Overweight and Obese Older Adults
Article first published online: 17 JUN 2013
© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 61, Issue 7, pages 1089–1094, July 2013
How to Cite
J Am Geriatr Soc 61:1089-1094, 2013.
- Issue published online: 15 JUL 2013
- Article first published online: 17 JUN 2013
- National Heart, Lung, and Blood Institute. Grant Number: HL076441–01A1
- National Institute on Aging. Grant Numbers: P30 AG021332, F32 AG039186
- National Center for Research Resources. Grant Number: M01-RR007122
- physical activity;
- weight loss;
To determine the independent effect of long-term physical activity (PA) and the combined effects of long-term PA and weight loss (WL) on inflammation in overweight and obese older adults.
Eighteen-month randomized, controlled trial.
The community infrastructure of cooperative extension centers.
Overweight and obese (body mass index >28.0 kg/m2) community-dwelling men and women aged 60 to 79 at risk for cardiovascular disease (CVD).
Physical activity + weight loss (PA + WL) (n = 98), PA only (n = 97), or successful aging (SA) health education (n = 93) intervention.
Biomarkers of inflammation (adiponectin, leptin, high-sensitivity interleukin (hsIL)-6, IL-6sR, IL-8, and soluble tumor necrosis factor receptor 1) were measured at baseline and 6 and 18 months.
After adjustment for baseline biomarker, wave, sex, and visit, leptin and hsIL-6 showed a significant intervention effect. Specifically, leptin was significantly lower in the PA + WL group (21.3 ng/mL, 95% confidence interval (CI) = 19.7–22.9 ng/mL) than in the PA (29.3 ng/mL, 95% CI = 26.9–31.8 ng/mL) or SA (30.3 ng/mL, 95% CI = 27.9–32.8 ng/mL) group (both P < .001), and hsIL-6 was significantly lower in the PA + WL group (2.1 pg/mL, 95% CI = 1.9–2.3 pg/mL) than in the PA (2.5 pg/mL, 95% CI = 2.3–2.7 pg/mL) or SA (2.4 pg/mL, 95% CI = 2.2–2.6 pg/mL) group (P = .02).
Addition of dietary-induced WL to PA reduced leptin and hsIL-6 more than PA alone and more than a SA intervention in older adults at risk for CVD. Results suggest that WL, rather than increased PA, is the lifestyle factor primarily responsible for improvement in the inflammatory profile.