Vitamin D and Physical Performance in Older Men and Women Visiting the Emergency Department Because of a Fall: Data from the Improving Medication Prescribing to reduce Risk Of FALLs (IMPROveFALL) Study

Authors

  • Nicole D. A. Boyé MD,

    1. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    2. Department of Surgery-Traumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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  • Christian Oudshoorn MD,

    1. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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  • Nathalie van der Velde MD PhD,

    1. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    2. Section of Geriatric Medicine, Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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  • Esther M. M. van Lieshout PhD,

    1. Department of Surgery-Traumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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  • Oscar J. de Vries MD PhD,

    1. Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
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  • Paul Lips MD PhD,

    1. Department Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
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  • Ed F. van Beeck PhD,

    1. Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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  • Peter Patka MD PhD,

    1. Emergency Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
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  • Tischa J. M. van der Cammen MD PhD

    Corresponding author
    1. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    2. Department of Medicine, Brighton and Sussex Medical School, Brighton, UK
    3. Faculty of Industrial Design Engineering, Delft University of Technology, Delft, the Netherlands
    • Address correspondence to Dr. T.J.M. Van der Cammen, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, the Netherlands. E-mail: t.vandercammen@erasmusmc.nl

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Abstract

Objectives

To investigate whether serum 25-hydroxy vitamin D (25(OH)D) is associated with physical performance in men and women.

Design

Cross-sectional.

Setting

Emergency departments (EDs) of five hospitals.

Participants

Older adults who visited an ED because of a fall (N = 616).

Measurements

Physical performance was assessed using the Timed Up and Go Test, the Five Time Sit to Stand Test, handgrip strength, and the tandem stand test. Multivariate linear regression was used to assess the association between physical performance and log-transformed 25(OH)D concentration adjusted for potential confounders.

Results

In men, higher serum 25(OH)D concentration was significantly associated with better handgrip strength (regression coefficient (B) = 3.86, 95% confidence interval (CI) = 2.04−5.69), faster TUG time (B = −2.82, 95% CI = −4.91 to −0.73), and faster FTSS time (B = −3.39, 95% CI = −5.67 to −1.11). In women, higher serum 25(OH)D concentration was significantly associated with faster TUG time (B = −2.68, 95% CI = −4.87 to −0.49).

Conclusion

A positive association was found between serum 25(OH)D level and physical performance in men and women. Intervention studies are needed of vitamin D–deficient older men and women to further investigate the effect of vitamin D supplementation in this group.

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