Cognitive Dysfunction and Greater Visit-to-Visit Systolic Blood Pressure Variability
Article first published online: 25 NOV 2013
© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 61, Issue 12, pages 2168–2173, December 2013
How to Cite
J Am Geriatr Soc 61:2168–2173, 2013.
- Issue published online: 12 DEC 2013
- Article first published online: 25 NOV 2013
- Indiana Alzheimer's Disease Center. Grant Number: P30AG10133
- NIH Clinical and Translational Science Institute. Grant Number: TL1 RR025759
- Eli Lilly and Company
- NIH. Grant Numbers: R01 CA101318 [PI], R01 AG19771 [PI], RC2 AG036535, P30 AG10133–18S1, U01 AG032984
- Indiana Economic Development Corporation. Grant Number: #87884
- ADNI. Grant Number: U01 AG024904
- Canadian Institutes of Health Research
To determine whether variability in blood pressure (BP) is negatively associated with performance on cognitive testing.
Multinational, longitudinal, observational cohort study.
The Alzheimer's Disease Neuroimaging Initiative study.
Individuals with a screening diagnosis of mild cognitive impairment or normal cognition (N = 626).
Mean, variance, and maximum BP were calculated based on measures collected from screening to 36 months. Analysis of covariance models were used to determine the association between BP measures and cognitive scores at 36 months after adjusting for covariates.
Greater variability in systolic (P < .05) but not diastolic (P > .18) BP was associated with worse global (Modified Alzheimer's Disease Assessment Scale Cognitive Component and Clinical Dementia Rating sum of boxes) and executive (Trail-Making Test Part B, Animal Fluency, and Vegetable Fluency) function and episodic memory (Rey Auditory Verbal Learning Test Total Score).
There is a clinically significant association between greater systolic BP variability and greater cognitive dysfunction. These results should be verified in other well-characterized cohorts, and the neuroanatomical pathophysiology underlying the observed greater cognitive impairment should be further explored.