These authors contributed equally to the manuscript.
Prevalence of and Potential Risk Factors for Mild Cognitive Impairment in Community-Dwelling Residents of Beijing
Article first published online: 25 NOV 2013
© 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society
Journal of the American Geriatrics Society
Volume 61, Issue 12, pages 2111–2119, December 2013
How to Cite
J Am Geriatr Soc 61:2111–2119, 2013.
- Issue published online: 12 DEC 2013
- Article first published online: 25 NOV 2013
- National Science Foundation of China. Grant Numbers: 30873458, 81173460, 81000633
- Beijing New Medical Discipline Based Group. Grant Number: 100270569
- Project of Institute of Basic Research in Clinical Medicine
- China Academy of Chinese Medical Sciences. Grant Number: Z0175
- Program for New Century Excellent Talents in University. Grant Number: NCET-10-0249
- mild cognitive impairment;
- risk factors;
- leisure activities
To estimate the prevalence of mild cognitive impairment (MCI) in Beijing, China, and to explore the potential protective and risk factors for MCI.
The Beijing Ageing Brain Rejuvenation Initiative (BABRI).
Participants randomly recruited from BABRI (N = 1,211).
Participants underwent a battery of neuropsychological examinations to determine cognitive function and answered a series of personal questions. The prevalence of MCI and its subtypes were computed using Petersen's criteria. Influencing factors for MCI were estimated based on participant medical history, lifestyle, diet, and leisure activities.
One thousand twenty (aged >55, mean 63.9 ± 6.6; 36.7% male) subjects completed the neuropsychological tests. The overall prevalence of MCI was 15.7%, with single-domain amnestic, multiple-domain amnestic, and nonamnestic subtype prevalences of 6.4%, 3.7%, and 5.6%, respectively. Eight hundred sixty-four subjects were used for the case–control analysis. Hypertension, diabetes mellitus, and cerebrovascular disease were found to be associated with MCI. Healthy diet and greater involvement in physical, intellectual, and social activities were associated with a lower risk of MCI.
The prevalence of MCI was compatible with that found in previous published reports, and the information on the epidemiology of MCI, especially risk factors, may help to explore therapeutic strategies and preventive approaches to delay conversion to dementia.