The effect of propofol on intravenous glucose tolerance test in rhesus monkey

Authors

  • Jong Min Kim,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
    2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea
    3. Medical Research Institute for Infectious Diseases, Seoul National University College of Medicine, Seoul, Korea
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    • These two authors contributed equally to this work.
  • Jun-Seop Shin,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
    2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea
    3. Medical Research Institute for Infectious Diseases, Seoul National University College of Medicine, Seoul, Korea
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    • These two authors contributed equally to this work.
  • Il Hee Yoon,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
    2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea
    3. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
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  • Byoung Hoon Min,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
    2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea
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  • Won Young Jeong,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
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  • Ga Eul Lee,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
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  • Min Sun Kim,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
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  • Ju Eun Kim,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
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  • Jae Yool Jang,

    1. Translational Xenotransplantation Research Center, Seoul, Korea
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  • Chung-Gyu Park

    Corresponding author
    1. Translational Xenotransplantation Research Center, Seoul, Korea
    2. Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea
    3. Medical Research Institute for Infectious Diseases, Seoul National University College of Medicine, Seoul, Korea
    4. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    5. Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
    • Correspondence

      Chung-Gyu Park, Department of Microbiology and Immunology, Translational Xenotransplantation Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, 110-799 Seoul, Korea.

      Tel.: +82 2 740 8007, 8308;

      fax: +82 2 743 0881;

      e-mail: chgpark@snu.ac.kr

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Abstract

Background

Many anesthetics have been shown to impair glucose metabolism and cause hyperglycemia. The aim of this study was to evaluate the effects of propofol on glucose metabolism and insulin secretion during intravenous glucose tolerance test (IVGTT) in rhesus monkey.

Methods

Serum cortisol, blood glucose, insulin, and C-peptide concentrations during IVGTT were measured in four rhesus monkeys under either conscious state or propofol anesthesia.

Results and Conclusions

The levels of serum cortisol significantly increased under conscious condition, whereas these levels remained constant under propofol anesthesia. In propofol group, the levels of serum insulin and C-peptide significantly increased compared with those in conscious group. Accordingly, glucose disposal capacity was significantly improved, and the time to return to basal glucose levels was shortened in propofol group. This study showed that propofol significantly increased insulin and C-peptide, and the corresponding improvement in glucose disposal may be related to reduction of serum cortisol in monkey.

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