Substrate determinants in the C99 juxtamembrane domains differentially affect γ–secretase cleavage specificity and modulator pharmacology
Version of Record online: 18 JAN 2013
© 2012 International Society for Neurochemistry
Journal of Neurochemistry
Volume 125, Issue 4, pages 610–619, May 2013
How to Cite
J. Neurochem. (2013) 125, 610–619.
- Issue online: 25 APR 2013
- Version of Record online: 18 JAN 2013
- Accepted manuscript online: 17 DEC 2012 12:00AM EST
- Manuscript Accepted: 13 DEC 2012
- Manuscript Revised: 12 DEC 2012
- Manuscript Received: 27 NOV 2012
Figure S1. Primer sequences utilized for the generation of the wild-type (DA) and the various mutant C99 constructs.
Figure S2. Relative abundance of various Aβ peptides secreted into media from cells expressing wild-type or mutant C99 γ-secretase substrates.
Figure S3. Dose-dependent inhibition of Aβ42 production in K28E mutant transfected HEK293T/17 cells.
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