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Figure S1. (a–d) Cell extracts obtained from HeLa cells treated with 0.5 mM ARS for 1 h (a).

Figure S2. (a) The domain architectures of wild-type (WT) TDP-43 or TDP-43 bearing mutation of serines (Ser403/404/409/410) to alanines (Ala) are shown schematically.

Figure S3. SH-SY5Y neuronal cells were untreated (Control) or treated with 0.25 mM ARS for 0.5 h, and then analyzed by fluorescence in situ hybridization, as indicated.

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