jnc12252-sup-0001-VideoS1.avivideo/avi93376KVideo S1. Time-lapse video showing GFP-wild type neurons treated with 100 μM UTP alone, indicating no significant neurite outgrowth.
jnc12252-sup-0002-VideoS2.avivideo/avi80651KVideo S2. Time-lapse video showing GFP-wild type neurons pretreated with IL-1β for 24 h. Then 100 μM UTP was added and neurite outgrowth visualized. Video 1 and 2 support the conclusion that P2Y2 receptor up-regulation by IL-1β and subsequent activation by UTP increase neurite outgrowth.

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