MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA
Article first published online: 11 JUN 2013
© 2013 International Society for Neurochemistry
Journal of Neurochemistry
Volume 126, Issue 3, pages 331–337, August 2013
How to Cite
J. Neurochem. (2013) 126 331–337.
- Issue published online: 18 JUL 2013
- Article first published online: 11 JUN 2013
- Accepted manuscript online: 18 MAY 2013 03:42AM EST
- Manuscript Accepted: 15 MAY 2013
- Manuscript Revised: 17 APR 2013
- Manuscript Received: 6 MAR 2013
- AVP ;
- deep sequencing;
Oxytocin (Oxt), produced in the hypothalamic paraventricular and supraoptic nuclei for transport to and release from the posterior pituitary, was originally discovered through its role in lactation and parturition. Oxt also plays important roles in the central nervous system by influencing various behaviors. MicroRNAs (miRNAs), endogenous regulators of many genes, are a class of small non-coding RNAs that mediate post-transcriptional gene silencing. We performed miRNA expression profiling of the mouse hypothalamus by deep sequencing. Among the sequenced and cross-mapped small RNAs, expression of known miRNAs and unknown miRNAs candidates were analyzed. We investigated in detail one miRNA, miR-24, and found that it is a novel regulator of Oxt and controls both transcript and peptide levels of Oxt. These results provide insights into potential neurohypophysial hormone regulation mediated by miRNAs.