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Figure S1. Representative tracing of currents through a receptor during the redox protocol. GABA responses were induced with the concentration that produced half the maximal response (EC50) for each mutant (see Table S1).

Figure S2. Comparison between wild-type and Cys-less α1β2γ2 GABAAR.

Figure S3. Concentration-response curves for single and double mutants in α and β subunits in a Cys-less background.

Figure S4. Concentration-response curves for double mutants in β subunits in a Cys-less background.

Figure S5. GABA-induced responses after DTT and Cu++/:phenanthroline application in single mutants (EC50 GABA was used).

Figure S6. Single cysteine mutations and drug effects.

Table S1. GABA concentration-response curves parameters.

Table S2. Cα-Cα distances between the cysteine pairs studied, according to the model.

Table S3. Drug binding to locations in transmembrane regions (TM) of ligand-gated ion channels.

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