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Figure S1. Inflammatory mediators in SH-SY5Y-DA cells. Unaltered levels of inflammatory mediators (caspase-1, p10 cleaved fragment of caspase-1 and Cox-2) were observed in SH-SY5Y-DA cells following exposure to MPP+ (100 μM) or rotenone (50 nM).

Figure S2. Restoration of calpain-calpastatin ratio by post-treatment with SNJ-1945. MPP+ or rotenone exposure induced dysregulation of calpain-calpastatin system by enhancing the ratio of active calpain to calpastatin; post-treatment with SNJ-1945 1–3 h ameliorated MPP+ or rotenone effects.

Figure S3. Attenuation of calpain activity by post-treatment with SNJ-1945.

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