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JNC12798-sup-0001-DataS1.txtplain text document1695KData S1. Protein microarray raw data file containing Z-binding scores: 3flag-GFP compared to 3flag-LRRK1.
JNC12798-sup-0002-DataS2.txtplain text document1693KData S2. Protein microarray raw data file containing Z-binding scores: 3flag-GFP compared to 3flag-LRRK2.
JNC12798-sup-0003-DataS3.txtplain text document1694KData S3. Protein microarray raw data file containing Z-binding scores: 3flag-LRRK1 compared to 3flag-LRRK2.
jnc12798-sup-0004-Supp-Info.pdfapplication/PDF19086K

Appendix S1. Supplementary Materials and methods.

Figure S1. LRRK1 and LRRK2 cellular phosphorylation sites map to distinct protein regions.

Figure S2. Visualization of LRRK1 and LRRK2 subcellular localization following stimulation by rhodamine-labeled epidermal growth factor.

Figure S3. EGF-induced translocation of LRRK1 in control cell lines and in cells with genetic depletion of LRRK2.

Figure S4. Co-localisation of EGF-stimulated eGFP-LRRK1 with endosomes EGF-stimulated eGFP-LRRK1-positive structures are endosomal as shown by costaining with the endosomal marker EEA1.

Table S1. List of interacting proteins identified via protein microarray.

Table S2. List of interacting proteins identified with AP-MS approach.

Table S3. List of primers used to generate lentiviral vectors expressing microRNA-based short hairpin RNA sequences.

jnc12798-sup-0005-Supp-Info.docxWord document10K 

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