Figure S1. Summary of rCBF before, during and after MCAO in mice. rCBF dropped significantly below 30% of baseline levels upon MCAO in each mouse in all experimental groups, and returned towards baseline rapidly after reperfusion.

Figure S2. Summary of mouse temperature at baseline and after MCAO.

Figure S3. Apoptotic cell detection on 6-μm brain sections from mice receiving IOX3/vehicle immediately before the surgery.

Figure S4. Effect of IOX3 on RBE4 cell viability.

Table S1. A list of primers used for RT-PCR.

Table S2. Mouse body weights at baseline, weight loss and mortality 24 h after the MCAO.

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