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Figure S1. Arctic Aβ42 binds to CHRNA7 with a higher affinity than wild-type Aβ42. An in vitro binding experiment using Arctic Aβ42 and wild-type Aβ42 was performed. Arctic Aβ42 bound to GST-CHRNA7 more strongly than wild-type Aβ42 while a band corresponding to a Aβ42 dimer (~8 kDa) was also detected. Aggregates were visible in the input sample used for in vitro binding experiment suggesting the self-accumulation of Arctic Aβ42 and wild-type Aβ42.

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