Catecholamines up integrates dopamine synthesis and synaptic trafficking (pages 1294–1305)
Zhe Wang, Faiza Ferdousy, Hakeem Lawal, Zhinong Huang, J. Gavin Daigle, Iyare Izevbaye, Olugbenga Doherty, Jerrad Thomas, Dean G Stathakis and Janis M. O’Donnell
Version of Record online: 3 NOV 2011 | DOI: 10.1111/j.1471-4159.2011.07517.x
Catecholamines up integrates dopamine synthesis and synaptic trafficking The highly reactive nature of dopamine heightens the oxidative risk of dopaminergic neurons. Mutations in the Drosophila gene Catecholamines up (Catsup), however, cause dominantly elevated dopamine pools, while increasing resistance to oxidative stress. This study demonstrates that Catsup regulates and coordinates dopamine synthesis and synaptic trafficking. This novel integration function has important implications for dopamine modulated behaviors and susceptibility to dopamine-linked disorders.