Clozapine functions through the prefrontal cortex serotonin 1A receptor to heighten neuronal activity via calmodulin kinase II–NMDA receptor interactions (pages 396–407)
Sudarshana Purkayastha, Jason Ford, Baishali Kanjilal, Souleymane Diallo, Joseph Del Rosario Inigo, Lorenz Neuwirth, Abdeslem El Idrissi, Zaghloul Ahmed, Andrzej Wieraszko, Efrain C. Azmitia and Probal Banerjee
Version of Record online: 15 DEC 2011 | DOI: 10.1111/j.1471-4159.2011.07565.x
How clozapine worksNerve signals in the analytical center of the brain prefrontal cortex (PFC) are impaired in Schizophrenia but how the therapeutic agent clozapine normalizes these signals is unknown. This study analyzes nerve signals and molecular interactions in the PFC to explain how clozapine works. Our findings unify multiple prior hypotheses into one mechanistic model for the action of clozapine.