Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice (pages 528–540)
Yongqi Rong, Peng Wei, Jennifer Parris, Hong Guo, Roberto Pattarini, Kristen Correia, Leyi Li, Sheila V. Kusnoor, Ariel Y. Deutch and James I. Morgan
Article first published online: 13 JAN 2012 | DOI: 10.1111/j.1471-4159.2011.07604.x
Do Cbln1 and Cbln2 have redundant functions in vivo? Cbln1 is a bi-functional ligand that bridges neurexins on pre-synaptic membranes to Grid2 on post-synaptic membranes in cerebellum, thereby stabilizing granule cell-Purkinje cell synaptic interactions. By using transgenic and knockout mice, we show that Cbln2 can exhibit functional redundancy with Cbln1 in cerebellum but it does not have the same properties as Cbln1 in thalamic neurons, implying one or both ligands utilize different receptors/mechanisms in these two brain region.