Control of neurite outgrowth by RhoA inactivation (pages 684–698)
Chan-Young Jeon, Mi-Young Moon, Jong-Hyun Kim, Hee-Jun Kim, Jae-Gyu Kim, Yi Li, Jae-Kwang Jin, Pyeung-Hyeun Kim, Hyoung-Chun Kim, Kathryn E. Meier, Yong-Sun Kim and Jae-Bong Park
Article first published online: 24 NOV 2011 | DOI: 10.1111/j.1471-4159.2011.07564.x
RhoA inactivation is required for neurite outgrowth of PC12 cells in response to cAMP. Hereby, we elucidated the mechanism of RhoA inactivation by cAMP: the phosphorylation of RhoA and the activation of p190RhoGAP and Rap1/ARAP3 participate in RhoA inactivation. Because neuronal regeneration is induced by RhoA inactivation, Rho inhibitors are emerging as the therapeutic reagents to promote neuronal regeneration.