Cynandione A mitigates ischemic injuries in rats with cerebral ischemia (pages 451–464)
Rongcai Yue, Xing Yuan, Xiaojun Liu, Jigang Zhang, Peng Jiang, Cheng He, Lei Shan, Yizhi Yu and Weidong Zhang
Article first published online: 14 MAR 2012 | DOI: 10.1111/j.1471-4159.2012.07682.x
Cynandione A mitigates ischemic injuriesCynandione A possesses potent antioxidant activities and shows neuroprotective actions both in vitro and in rats with transient focal cerebral ischemia. Cynandione A suppresses DPYSL2 cleavage and antagonizes the rises in HMGB1 levels in the brain tissues of ischemic rats, which could contribute to the neuroprotective properties. Cynandione A should be further explored as a neuroprotective agent for ischemic stroke.