Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways (pages 321–332)
Alexander Widiapradja, Viktor Vegh, Ker Zhing Lok, Silvia Manzanero, John Thundyil, Mathias Gelderblom, Yi-Lin Cheng, Dale Pavlovski, Sung-Chun Tang, Dong-Gyu Jo, Tim Magnus, Sic L. Chan, Christopher G. Sobey, David Reutens, Milan Basta, Mark P. Mattson and Thiruma V. Arumugam
Version of Record online: 27 APR 2012 | DOI: 10.1111/j.1471-4159.2012.07754.x
Intravenous immunoglobulin for Stroke Intravenous immunoglobulin(IVIg) is a therapeutic modality approved for the treatment of various condition. This study was performed in order to understand the mechanism ofhow IVIg elicits its neuroprotective effect in stroke and amyloid beta induced neuronal apoptosis. The findings from this study showed that IVIg elicits its neuroprotective effects by not only inhibiting the cell death pathways but also elevating the anti-apoptotic protein Bcl2. This study provides a better understanding of how IVIg plays a role in neuroprotection and therefore provides more evidence to encourage the use of IVIg as therapeutic modality in stroke and Alzheimer’s disease.