AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin (pages 714–726)
Xenia Gorny, Marina Mikhaylova, Christian Seeger, Pasham Parameshwar Reddy, Carsten Reissner, Björn H. Schott, U. Helena Danielson, Michael R. Kreutz and Constanze Seidenbecher
Article first published online: 10 JUL 2012 | DOI: 10.1111/j.1471-4159.2012.07828.x
AKAP partner exchange in the postsynapse: caldendrin and calmodulin compete for binding How does calcium affect the composition of postsynaptic signaling complexes? AKAP79/150, a key adaptor for receptor-enzyme complexes, binds to and is regulated by Ca2+/calmodulin. We show now that AKAP79/150 also interacts with caldendrin, which competes with calmodulin in a calcium-dependent way. The complex binding mechanism makes caldendrin an interesting novel player in the signaling toolkit of the AKAP interactome.