Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase (pages 1065–1080)
Vladimir Farar, Franziska Mohr, Marie Legrand, Boris Lamotte d’Incamps, Jan Cendelin, Jacqueline Leroy, Marc Abitbol, Veronique Bernard, Frédéric Baud, Vincent Fournet, Pascal Houze, Jochen Klein, Benoit Plaud, Jan Tuma, Martina Zimmermann, Philippe Ascher, Anna Hrabovska, Jaromir Myslivecek and Eric Krejci
Article first published online: 3 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07856.x
Mice lacking central acetylcholinesterase (AChE) adapt to this deficit and show very few physiological defects. Surprisingly, however, they are strongly affected by donepezil, a clinically used AChE inhibitor often assumed to act selectively on central AChE. The effect of donepezil in the knockout mice involves the AChE of the autonomic nervous system, which thus appears as a major pharmacological target.