Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death (pages 226–238)
Se Jin Jeon, Seol-Heui Han, Sung-Il Yang, Ji woong Choi, Kyoung Ja Kwon, Seung Hwa Park, Hahn Young Kim, Jae Hoon Cheong, Jong Hoon Ryu, Kwang Ho Ko, David G Wells and Chan Young Shin
Article first published online: 22 AUG 2012 | DOI: 10.1111/j.1471-4159.2012.07886.x
Neurological insults such as excessive glutamate or stroke induce FMRP expression and activation of PI3K-Akt pathway in primary cortical neurons, which may form positive feedback activation loop resulting in up-regulation of anti-apoptotic Bcl-xL expression and increased cell survival. This study provides experimental evidences that stimuli-induced FMRP expression underlies well-regulated neuronal cell survival system under excitotoxic insult conditions by modulating PI3K-Akt pathway.