Novel cerebrospinal fluid and serum autoantibody targets for clinically isolated syndrome (pages 568–577)
Myrthe Rouwette, Klaartje Somers, Cindy Govarts, Peter P. De Deyn, Raymond Hupperts, Bart Van Wijmeersch, Brigit A. De Jong, Marcel M. Verbeek, Vincent Van Pesch, Christian Sindic, Luisa M. Villar, José C. Álvarez-Cermeño, Piet Stinissen and Veerle Somers
Article first published online: 28 SEP 2012 | DOI: 10.1111/jnc.12005
Clinically isolated syndrome (CIS) is a possible first manifestation of multiple sclerosis (MS) and limited information is available on the identity of antigens targeted by antibodies in CIS. We applied a phage display technique and identified a panel of six novel candidate antigens, to which both cerebrospinal fluid and serum antibody reactivity could be detected in CIS and MS. Moreover, prognostic potential to predict conversion to MS in CIS patients could be demonstrated for two antigens.