Prion protein participates in the regulation of classical and alternative activation of BV2 microglia (pages 168–174)
Fushan Shi, Lifeng Yang, Mohammed Kouadir, Yang Yang, Tianjian Ding, Jihong Wang, Xiangmei Zhou, Xiaomin Yin and Deming Zhao
Article first published online: 15 NOV 2012 | DOI: 10.1111/jnc.12053
Prion protein regulates classical and alternative activation of microglia
Earlier studies have suggested that cellular prion protein has a neuro-protective function. In this study, we demonstrated that cellular prion protein is involved in the modulation of the shift of microglia from a quiescent phenotype to an activated state and in the regulation of the microglial response during classical and alternative activation. The result provides the basic data for further study of cellular prion protein context- dependen neuro-protective function.