AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway (pages 347–362)
Irene Llorente-Folch, Ignasi Sahún, Laura Contreras, María José Casarejos, Josep María Grau, Takeyori Saheki, María Angeles Mena, Jorgina Satrústegui, Mara Dierssen and Beatriz Pardo
Article first published online: 7 JAN 2013 | DOI: 10.1111/jnc.12096
The nigrostriatal dopamine (DA) system constitutes a target of Aralar/AGC-deficiency. A fall in vesicular monoamine transporter-2 (VMAT2) levels and GSH/GSSG ratio associated with increased DA metabolism was observed in Aralar-KO striatum. A failure in the Aralar-Malate aspartate shuttle pathway, resulting in limited mitochondrial NADH formation, and ROS detoxifying capacity might constitute an important factor at the origin of DA degeneration.