Seipin regulates excitatory synaptic transmission in cortical neurons (pages 478–489)
Shunhui Wei, Stephanie Li-Ying Soh, Wenjie Qiu, Wulin Yang, Cheyenne Jia-Yan Seah, Jing Guo, Wei-Yi Ong, Zhiping P. Pang and Weiping Han
Article first published online: 27 DEC 2012 | DOI: 10.1111/jnc.12099
Seipin, an ER protein with high-level expression in brain, is implicated in a broad spectrum of motoneuron diseases. Seipin specifically regulates excitatory postsynaptic currents (EPSCs) as knockdown (KD) of Seipin results in significantly reduced AMPA receptor (AMPA-R)-mediated currents. Moreover, Seipin KD causes decreased total and surface AMPA-R levels. We conclude that Seipin regulates synaptic transmission through a postsynaptic mechanism.