Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain (pages 749–756)
Aurelien Caballero-Caballero, Tobias Engel, Jaime Martinez-Villarreal, Amaya Sanz-Rodriguez, Patrick Chang, Mark Dunleavy, Claire M. Mooney, Eva M. Jimenez-Mateos, Clara K. Schindler and David C. Henshall
Article first published online: 15 JAN 2013 | DOI: 10.1111/jnc.12133
‘Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain’
We identify a novel subcellular localization for FOXO3a, a transcription factor involved in development, life-span, and apoptosis control. We show that FOXO3a resides in mitochondria in the mouse, rat, and human hippocampus, where it may target mitochondrial DNA. We also found changes to levels of mitochondrial FOXO3a in experimental seizure models and human epilepsy. These findings open a new area of research on FOXO3a.