Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease (pages 157–171)
Misha Zilberter, Anton Ivanov, Sofya Ziyatdinova, Marat Mukhtarov, Anton Malkov, Alan Alpár, Giuseppe Tortoriello, Catherine H. Botting, Lívia Fülöp, Alex A. Osypov, Asla Pitkänen, Heikki Tanila, Tibor Harkany and Yuri Zilberter
Article first published online: 10 JAN 2013 | DOI: 10.1111/jnc.12127
When Alzheimer's disease is diagnosed, it is too late for any known treatment. Earlier stages are characterized by metabolic crisis and neuronal hyperactivity leading to increased energy demands, thus creating a vicious circle. We show that dietary supplementation with natural energy substrates in Alzheimer's mice model breaks this vicious circle reversing epileptogenesis in vivo and correcting neuronal pathologies ex vivo/in vitro.