The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway (pages 620–633)
Hadhemi Kaddour, Yosra Hamdi, David Vaudry, Magalie Basille, Laurence Desrues, Jérôme Leprince, Hélène Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri and Olfa Masmoudi-Kouki
Version of Record online: 19 FEB 2013 | DOI: 10.1111/jnc.12140
We proposed the following cascade for the neuroprotective effect of octadecaneuropeptide (ODN) against 6-OHDA-induced neuronal death: ODN provokes a stimulation of ERK phosphorylation, through a PKC-dependent mechanism. Activation of ERK counteracts the inhibition of Bcl-2 and the stimulation of the pro-apoptotic gene Bax induced by reactive oxygen species (ROS) formation and glutathione (GSH) depletion. These data may allow the development of new strategies for cerebral injury treatment.