Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis (pages 698–712)
Zhengwei Li, Chengdong Sun, Tao Zhang, Jianbing Mo, Qiong Shi, Xianfeng Zhang, Maochun Yuan, Long Chen, Xueqiang Mao, Rutong Yu and Xiuping Zhou
Version of Record online: 19 APR 2013 | DOI: 10.1111/jnc.12249
Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis
Synaptogenesis is a complicated process of interaction between extracellular factors, such BDNF, and intracellular signaling, such as Rho family small GTPases. However, the mechanism that BDNF activated Rho family small GTPases and affected cytoskeletal reorganization and synapse formation remains unclear. In this sudy, we reported that GGT mediates BDNF-induced neuronal synaptogenesis through small GTPase Rac1 activation.