Novel systemically active galanin receptor 2 ligands in depression-like behavior (pages 114–123)
Indrek Saar, Jaanus Lahe, Kent Langel, Johan Runesson, Kristin Webling, Jaak Järv, Jussi Rytkönen, Ale Närvänen, Tamas Bartfai, Kaido Kurrikoff and Ülo Langel
Version of Record online: 31 MAY 2013 | DOI: 10.1111/jnc.12274
We utilize several chemical modifications to increase in vivo usability of peptide-based ligands, acting upon CNS. Accordingly, we introduce a series of novel systemically active galanin analogues, with modest preferential binding towards GalR2, and demonstrate their ability to attenuate depression-like behavior via brain GalR2 in different mouse models of depression.