Human choroid plexus papilloma cells efficiently transport glucose and vitamin C (pages 403–414)
Viviana Ulloa, María García-Robles, Fernando Martínez, Katterine Salazar, Karin Reinicke, Fernando Pérez, David F. Godoy, Alejandro S. Godoy and Francisco Nualart
Article first published online: 29 MAY 2013 | DOI: 10.1111/jnc.12295
In choroid plexus papilloma cells, the vitamin C transporters SVCT2 and GLUT1 are polarized to the basolateral epithelial membrane, where SVCT2 is essential for AA flux from the blood vessels into the brain. However, neutrophils, attracted by inflammation or the tumor microenvironment, can oxidize extracellular AA to DHA, thereby enabling its uptake through GLUT1. For the first time, we show the in vivo and in vitro basolateral co-distribution of functional SVCT2 and GLUT1 in epithelial cells. We postulate that patients with choroid plexus papillomas may continue to transport vitamin C from the blood to CSF. However, increased transport of oxidized vitamin C could generate pro-oxidative conditions that may help control tumor growth.