You have free access to this content

Journal of Neurochemistry

Cover image for Journal of Neurochemistry

November 2013

Volume 127, Issue 3

Pages 299–433

  1. EDITORIAL HIGHLIGHT

    1. Top of page
    2. EDITORIAL HIGHLIGHT
    3. ORIGINAL ARTICLES
    4. HIGHLIGHTED ARTICLE
    5. ORIGINAL ARTICLES
    1. You have free access to this content
      A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system (pages 299–302)

      Eric J. Murphy

      Article first published online: 30 SEP 2013 | DOI: 10.1111/jnc.12439

      Read the full articleUnesterified docosahexaenoic acid is protective in neuroinflammation’ on doi: 10.1111/jnc.12392.

  2. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIAL HIGHLIGHT
    3. ORIGINAL ARTICLES
    4. HIGHLIGHTED ARTICLE
    5. ORIGINAL ARTICLES
    1. Signal Transduction & Synaptic Transmission

      You have free access to this content
      TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling (pages 303–313)

      Jeanine H. Heiser, Anita M. Schuwald, Giacomo Sillani, Lian Ye, Walter E. Müller and Kristina Leuner

      Article first published online: 19 AUG 2013 | DOI: 10.1111/jnc.12376

      Thumbnail image of graphical abstract

      Alterations in synaptic plasticity are considered to play an important role in the pathogenesis of depression. Beside several other proteins, TRPC6 channels regulate synaptic plasticity. This study demonstrates that different pathways including Ras/MEK/ERK, PI3K/Akt, and CAMKIV are involved in the improvement of synaptic plasticity by the TRPC6 activator hyperforin, the antidepressant active constituent of St. John's wort extract.

    2. You have free access to this content
      Circadian phase-dependent effect of nitric oxide on L-type voltage-gated calcium channels in avian cone photoreceptors (pages 314–328)

      Michael L. Ko, Liheng Shi, Cathy C.-Y. Huang, Kirill Grushin, So-Young Park and Gladys Y.-P. Ko

      Article first published online: 22 AUG 2013 | DOI: 10.1111/jnc.12384

      Thumbnail image of graphical abstract

      In cone photoreceptors, the protein expression of neural nitric oxide synthase (nNOS) and NO production are under circadian control. NO-cGMP-protein kinase G (PKG) signaling serves in the circadian output pathway to regulate the circadian rhythms of L-type voltage-gated calcium channels (L-VGCCs) in part through regulating the phosphorylation states of extracellular-signal-regulated kinase (Erk) and protein kinase B (Akt).

    3. You have free access to this content
      δ-opioid receptor activation leads to neurite outgrowth and neuronal differentiation via a STAT5B-Gαi/o pathway (pages 329–341)

      Eirini-Maria Georganta, Lambrini Tsoutsi, Maria Gaitanou and Zafiroula Georgoussi

      Article first published online: 18 SEP 2013 | DOI: 10.1111/jnc.12386

      Thumbnail image of graphical abstract

      We propose a novel signalling pathway for δ-opioid receptor (δ-ΟR)-mediated neurotropic events. STAT5B interacts with the δ-ΟR and upon prolonged receptor activation phosphorylates STAT5B in a Gi/Go dependent manner leading to increased neuronal survival, neurite outgrowth and differentiation. These findings contribute to a better understanding of the molecular and cellular events following δ-OR activation and suggest a possible neuroprotective role opioids could exert.

    4. Bioenergetics & Metabolism

      You have free access to this content
      In vivo induction of P-glycoprotein expression at the mouse blood–brain barrier: an intracerebral microdialysis study (pages 342–352)

      Gary N. Y. Chan, Victor Saldivia, Yingbo Yang, Henrianna Pang, Inés de Lannoy and Reina Bendayan

      Article first published online: 14 JUL 2013 | DOI: 10.1111/jnc.12344

      Thumbnail image of graphical abstract

      Applying microdialysis, distribution of quinidine, a P-gp substrate, in mouse brain extracellular fluid (ECF) was investigated following ligand-mediated P-glycoprotein (P-gp) induction at the blood–brain barrier (BBB). We demonstrated that a PXR agonist (dexamethasone) significantly up-regulated P-gp in brain capillaries and reduced quinidine brain ECF concentrations. Our data suggest that drug–drug interactions as a result of P-gp induction at the BBB are possible.

    5. You have free access to this content
      Metabolic products of [2-13C]ethanol in the rat brain after chronic ethanol exposure (pages 353–364)

      Jie Wang, Hongying Du, Xiaoxian Ma, Brian Pittman, Laura Castracane, Ting-Kai Li, Kevin L. Behar and Graeme F. Mason

      Article first published online: 23 SEP 2013 | DOI: 10.1111/jnc.12405

      Thumbnail image of graphical abstract

      The liver converts ethanol to acetate, which may contribute to long-term adaptation to drinking. Astroglia oxidize acetate and generate neurochemicals, while neurons and glia may also oxidize ethanol. When 13C-ethanol is administered intravenously, 13C-glutamine, glutamate, and GABA, normalized to 13C-acetate, were higher in chronic ethanol-exposed rats than in control rats, suggesting that ethanol exposure increases cerebral oxidation of circulating acetate.

    6. You have free access to this content
      In vivo NMR studies of regional cerebral energetics in MPTP model of Parkinson's disease: recovery of cerebral metabolism with acute levodopa treatment (pages 365–377)

      Puneet Bagga, Anup N. Chugani, Komanduri S. Varadarajan and Anant B. Patel

      Article first published online: 16 SEP 2013 | DOI: 10.1111/jnc.12407

      Thumbnail image of graphical abstract

      Cerebral atrophy, neurometabolite homeostasis, and neural energetics have been evaluated in an MPTP model of Parkinson's disease using MRI, in vivo 1H MRS and 1H-[13C]-NMR spectroscopy, respectively. MPTP treatment led to reduced paw grip strength and neuronal function. Acute Levodopa treatment was able to recover the diminished motor function and cerebral function. CMRGlc, Cerebral metabolic rate of glucose oxidation; MPTP, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin.

  3. HIGHLIGHTED ARTICLE

    1. Top of page
    2. EDITORIAL HIGHLIGHT
    3. ORIGINAL ARTICLES
    4. HIGHLIGHTED ARTICLE
    5. ORIGINAL ARTICLES
    1. ORIGINAL ARTICLES

      Neuroinflammation & Neuroimmunology
      You have full text access to this OnlineOpen article
      Unesterified docosahexaenoic acid is protective in neuroinflammation (pages 378–393)

      Sarah K. Orr, Sara Palumbo, Francesca Bosetti, Howard T. Mount, Jing X. Kang, Carol E. Greenwood, David W. L. Ma, Charles N. Serhan and Richard P. Bazinet

      Article first published online: 28 AUG 2013 | DOI: 10.1111/jnc.12392

      Thumbnail image of graphical abstract

      Our study shows that chronically increased brain unesterified DHA levels, but not solely phospholipid DHA levels, attenuate neuroinflammation. Similar attenuations occur with acute increases in brain unesterified DHA or 17S-HpDHA levels, highlighting the importance of an available pool of precursor unesterified DHA for the production of enzymatically derived specialized pro-resolving mediators that are critical in the regulation of neuroinflammation.

      Read the Editorial Highlight for this article on doi: 10.1111/jnc.12439.

  4. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIAL HIGHLIGHT
    3. ORIGINAL ARTICLES
    4. HIGHLIGHTED ARTICLE
    5. ORIGINAL ARTICLES
    1. Neuroinflammation & Neuroimmunology

      You have free access to this content
      Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway (pages 394–402)

      Jillian C. Nissen, David L. Selwood and Stella E. Tsirka

      Article first published online: 18 SEP 2013 | DOI: 10.1111/jnc.12404

      Thumbnail image of graphical abstract

      Despite the 40-year history of the tetrapeptide tuftsin (TKPR), a macrophage and microglial activator, its mechanism of action has not been defined. Here, we report that the tuftsin-mediated anti-inflammatory M2 shift in microglia is caused specifically by tuftsin binding to the receptor neuropilin-1 (Nrp1) and signaling through TGFβ receptor-1, a coreceptor of Nrp1. We further show that tuftsin signals via the canonical TGFβ pathway and promotes TGFβ release from target cells.

    2. Molecular Basis of Disease

      You have free access to this content
      Human choroid plexus papilloma cells efficiently transport glucose and vitamin C (pages 403–414)

      Viviana Ulloa, María García-Robles, Fernando Martínez, Katterine Salazar, Karin Reinicke, Fernando Pérez, David F. Godoy, Alejandro S. Godoy and Francisco Nualart

      Article first published online: 29 MAY 2013 | DOI: 10.1111/jnc.12295

      Thumbnail image of graphical abstract

      In choroid plexus papilloma cells, the vitamin C transporters SVCT2 and GLUT1 are polarized to the basolateral epithelial membrane, where SVCT2 is essential for AA flux from the blood vessels into the brain. However, neutrophils, attracted by inflammation or the tumor microenvironment, can oxidize extracellular AA to DHA, thereby enabling its uptake through GLUT1. For the first time, we show the in vivo and in vitro basolateral co-distribution of functional SVCT2 and GLUT1 in epithelial cells. We postulate that patients with choroid plexus papillomas may continue to transport vitamin C from the blood to CSF. However, increased transport of oxidized vitamin C could generate pro-oxidative conditions that may help control tumor growth.

    3. You have free access to this content
      Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease (pages 415–425)

      Valeriy G. Ostapchenko, Flavio H. Beraldo, Andre L. S. Guimarães, Sanju Mishra, Monica Guzman, Jue Fan, Vilma R. Martins, Vania F. Prado and Marco A. M. Prado

      Article first published online: 27 MAY 2013 | DOI: 10.1111/jnc.12296

      Thumbnail image of graphical abstract

      Prion protein (PrPC) and metabotropic glutamate receptors (mGluR) are implicated in Alzheimer's disease (AD). We found age-dependent increase in PrPC processing, ADAM10 and mGluR1 levels in AD mouse model. These changes could be reproduced in cultured cortical neurons treated with Aβ peptide. Our findings suggest that increased levels of Aβ can trigger compensatory responses that may affect neuronal toxicity.

    4. You have free access to this content
      BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia (pages 426–433)

      Chengren Li, Teng Guan, Xueping Chen, Wenyan Li, Qiyan Cai, Jianqin Niu, Lan Xiao and Jiming Kong

      Article first published online: 5 JUN 2013 | DOI: 10.1111/jnc.12314

      Thumbnail image of graphical abstract

      Pre-myelinating oligodendrocytes (preOLs) are known to be highly vulnerable to ischemic insults. It remains unclear, however, how preOLs die. This study shows that BNIP3, a proapoptotic member of the Bcl-2 family proteins, is a mediator of hypoxia/ischemia-induced preOLs death. The BNIP3 cell death pathway may therefore be a new target for protecting oligodendrocytes from death after stroke.

SEARCH

SEARCH BY CITATION