Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs (pages 750–761)
C. Makena Hightower, Kuixing Zhang, José P. Miramontes-González, Fangwen Rao, Zhiyun Wei, Andrew J. Schork, Caroline M. Nievergelt, Nilima Biswas, Manjula Mahata, Nina Elkelis, Laurent Taupenot, Mats Stridsberg, Michael G. Ziegler and Daniel T. O'Connor
Article first published online: 19 JUL 2013 | DOI: 10.1111/jnc.12346
We propose the following to describe effects of human delta-sarcoglycan (SGCD) variation on sympathetic and cardio-metabolic traits. SGCD variation alters expression, major allele A to minor allele G, augmenting sympathochromaffin norepinephrine (NE) and CHGB release. Increased plasma NE negatively impacts systemic vascular compliance, while mobilizing free fatty acids. Common variation gives rise to phenotypic consequences and without apparent myocardial involvement.