Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture (pages 88–100)
Gabriele Loers, Vedangana Saini, Bibhudatta Mishra, Florentia Papastefanaki, David Lutz, Sidhartha Chaudhury, Daniel R. Ripoll, Anders Wallqvist, Sheraz Gul, Melitta Schachner and Gurcharan Kaur
Article first published online: 23 SEP 2013 | DOI: 10.1111/jnc.12408
Polysialic acid (PSA) plays important roles in nervous system development, as well as synaptic plasticity and regeneration in the adult. 5-Nonyloxytryptamine oxalate (5-NOT) mimics PSA and triggers PSA-mediated functions in neurons and glial cells. 5-NOT stimulates neuritogenesis, myelination and Schwann cell migration. This study sets the basis to develop a PSA-mediated therapy of acute and chronic nervous system diseases.