Changes in CNS cells in Hyperammonemic portal hypertensive rats (pages 431–444)
Silvina Tallis, Laura R. Caltana, Pablo A. Souto, Amalia E. Delfante, Néstor R. Lago, Alicia Brusco and Juan C. Perazzo
Version of Record online: 24 OCT 2013 | DOI: 10.1111/jnc.12458
Rats with pre-hepatic portal hypertension because of partial portal vein ligation afford a model of minimal hepatic encephalopathy that developed hyperammonemia. The cellular changes found here were similar to those described in ischemic conditions. Besides, a high expression of HIF-1α in cortical neurons was observed. It is likely that a hypoxia-like state is triggered via ammonia occupying the binding domain of HIF-1α and thereby preventing its degradation and inducing its stabilization, leading to the over-expression of P-gp and the Epo-R.