KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ (pages 686–700)
Angela Vogt-Eisele, Carola Krüger, Kerstin Duning, Daniela Weber, Robert Spoelgen, Claudia Pitzer, Christian Plaas, Gisela Eisenhardt, Annette Meyer, Gerhard Vogt, Markus Krieger, Eva Handwerker, Dirk Oliver Wennmann, Thomas Weide, Boris V. Skryabin, Matthias Klugmann, Hermann Pavenstädt, Matthew J. Huentelmann, Joachim Kremerskothen and Armin Schneider
Version of Record online: 28 OCT 2013 | DOI: 10.1111/jnc.12480
KIBRA/WWC1 has been genetically associated with human episodic memory. KIBRA has been shown to be post-synaptically localized, but its function remained obscure. Here, we show that KIBRA shields PKMζ, a kinase previously linked to memory maintenance, from proteasomal degradation via direct interaction. KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMζ levels. Our findings support a role for KIBRA in memory, and unveil a novel function for this protein.