A new semisynthetic derivative of sauroine induces LTP in hippocampal slices and improves learning performance in the Morris Water Maze (pages 864–876)
Mariana Vallejo, Sebastián Loyola, Darwin Contreras, Gonzalo Ugarte, Diego Cifuente, Gabriela Ortega, José L. Cabrera, Marc Zeise, Carlos Tonn, Mario Carreño, Ricardo Delgado, Bernardo Morales and Mariel Agnese
Version of Record online: 24 MAR 2014 | DOI: 10.1111/jnc.12685
A semisynthetic derivative of sauroine, diacetyl sauroine (DAS), induces chemical long-term potentiation in rat hippocampal slices increasing the NMDA receptor-dependent current. 2 mg/kg prior to each session in a Morris Water Maze (MWM) improves behavior performance. In slices prepared from the tested rats the electrical stimulation-dependent long-term potentiation (LTP) was greatly enhanced. Therefore, DAS may have potency as a nootropic drug against the memory decline.