2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice (pages 940–954)
Eva-Verena Schaible, Julia Windschügl, Wiesia Bobkiewicz, Yordan Kaburov, Larissa Dangel, Tobias Krämer, Changsheng Huang, Anne Sebastiani, Clara Luh, Christian Werner, Kristin Engelhard, Serge C. Thal and Michael K.E. Schäfer
Version of Record online: 2 APR 2014 | DOI: 10.1111/jnc.12708
We examined neuroprotective effects of 2-methoxyestradiol (2ME2) and the hypoxia-inducible factor 1-α (HIF-1α) response following traumatic brain injury in mice. Early 2ME2 administration reduced the secondary brain damage and neuronal HIF-1α probably involving ubiquitin proteasome system-mediated degradation. The up-regulation of neuropathological HIF-1α target genes and pro-apoptotic BNIP3 protein was attenuated. We propose that the inhibition of a maladaptive HIF-1α response may contribute to 2ME2-mediated neuroprotection.