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Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives
Article first published online: 23 NOV 2012
© 2012 Wiley Periodicals, Inc.
Journal of Cosmetic Dermatology
Volume 11, Issue 4, pages 310–317, December 2012
How to Cite
Stamford, N. P. J. (2012), Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives. Journal of Cosmetic Dermatology, 11: 310–317. doi: 10.1111/jocd.12006
- Issue published online: 23 NOV 2012
- Article first published online: 23 NOV 2012
- Manuscript Accepted: 23 AUG 2012
- ascorbic acid;
- vitamin C;
Topically applied antioxidants exert their benefits by offering protection from damaging free radicals and over-the-counter cosmeceuticals incorporating antioxidants are among the most popular anti-aging products available. One potent antioxidant of particular note, vitamin C, has been extensively utilized because it possesses a variety of other cutaneous benefits including photoprotection from UV A & B, neocollagenesis, inhibition of melanogenesis and improvement of a variety of inflammatory skin disorders. However, the instability of this water-soluble vitamin, together with difficulties associated with its topical delivery, has presented issues for the formulation chemist. This article reviews the scientific data and clinical studies that underpin the stability, percutaneous absorption, and cutaneous effects of vitamin C together with its commonly utilized, commercially available derivatives.